Somatic mutations arise in the DNA of all the cells of the human body and occur throughout life. They are the consequence of mutational processes that may be exogenous in origin or due to endogenous cellular activities, and are a key component in understanding cancer development and progression. Different mutational processes generate observable patterns of mutation within the genome. These patterns are called mutational signatures.

Signal is the product of the Physiology of Mutagenesis research team at University of Cambridge, as part of the COMSIG Consortium. With teams in Cambridge and London, COMSIG is dedicated to exploring the biological underpinnings of mutational signatures and their potential clinical applications.

Signal is the most up-to-date repository of knowledge and expertise in the field of mutational signatures, and provides a comprehensive workflow for your own mutational signature analysis.