We extracted substitution and rearrangement signatures from 3,107 cancer samples generated by the International Cancer Genome Consortium. Signatures were extracted independently for each organ of origin and then clustered to form a set of reference signatures. This updated framework for signature extraction highlights signature variability across organs, and leverages the organ-specificity of signatures for improved fitting. The heatmap below shows the prevelance of the different reference signatures in samples from each organ. Click here for further information.